Cell Cure Neurosciences is a subsidiary of Lineage Cell Therapeutics, Inc., a clinical-stage biotechnology company developing novel cellular therapies to treat unmet medical needs. Our programs are based on proprietary cell-based therapy platform and associated development and manufacturing capabilities. With our platform we develop and manufacture specialized, terminally-differentiated human cells from our pluripotent and progenitor cell starting materials. These differentiated cells are developed either to replace or support cells that are dysfunctional or absent due to degenerative disease or traumatic injury, or administered as a means of helping the body mount an effective immune response to cancer.
Cell Cure is currently conducting in process development and production for products in Lineage Cell Therapeutics’ pipeline:
- OpRegen® – a cell replacement therapy comprised of retinal pigment epithelium cells and currently being tested in a Phase 1/2a multicenter clinical trial for the treatment of advanced dry age-related macular degeneration (dry AMD) with geographic atrophy. The development of OpRegen has been partially supported by more than $14 million of grants from the Israel Innovation Authority. OpRegen has been granted Fast Track designation from the U.S. Food and Drug Administration (FDA).
- OPC1 – a cell replacement therapy comprised of oligodendrocyte progenitor cells and currently being tested in a Phase 1/2a multicenter clinical trial for the treatment of acute spinal cord injuries (SCI). The development of OPC1 has been partially funded by a $14.3 million grant from the California Institute for Regenerative Medicine or CIRM. OPC1 has received Regenerative Medicine Advanced Therapy (RMAT) designation for the treatment of acute SCI and has been granted Orphan Drug Designation by the FDA.
- VAC2 – an allogeneic (non-patient-specific or “off-the-shelf”) cancer immunotherapy comprised of mature, antigen-presenting dendritic cells and currently being tested in a Phase I clinical trial in patients with non-small cell lung cancer (NSCLC). VAC2 has been partially supported by Cancer Research UK, the world’s largest independent cancer research charity, and which is responsible for costs and conduct of the clinical trial.
In-House GMP Production Facility